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KMID : 0379519970130030281
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한국독성학회지
1997 Volume.13 No. 3 p.281 ~ p.291
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Subacute Toxicity of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection in Rabbits
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Shin Kwang-Soon
Cho Seong-Whan
Yun Hyo-In
Kim Chul-Joong
Shin Hyun-Jin
Nam Sang-Min
Park Young-Mi
Choi Eun-Ah
Kim Eun
Yoon Won-Kee
Son Hwa-Young
Song Dong-Ho
Park Jong-Il
Cha Shin-Woo
Ahn Chang-Nam
Shin Hyeong-Soon
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Abstract
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The subacute toxicity of the combined vaccine (KGCC-95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection, recently developed by Korea Green Cross Corporation, was investigated. KGCC-95VI was subcutaneously administered into the both sexes of New Zealand White rabbits at the dosage of 0, 10. 50 and 250 ml/kg body weight (20, 100 and 500 times the expected clincal dose) once a day for 30 days. There were no deaths and clinical findings during the experiment period. In both sexes. there were no statistically significant differences between the treated and control groups in urinalysis tests, hematological tests, blood chemistry tests and pathological examinations. The KGCC-95VI is considered not to have the subacute toxicity in the rabbits.
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KEYWORD
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Japanese encephalitis, Hantaan virus infection, Vaccine, Subacute toxicity, Rabbits
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